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PREVU* Skin Sterol Test
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Trial
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Publications/Presentations
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Status
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Stress Test Study
- The Cleveland Clinic Foundation
- Dr. Dennis Sprecher
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- 31st Annual Oak Ridge Conference, April 1999
- Published in Journal of Clinical Chemistry, 2001
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Completed |
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Response to Therapy
- The Cleveland Clinic Foundation
- Dr. Dennis Sprecher
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- American Association for Clinical Chemistry, July 1999
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Completed |
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Angiography Pivotal Study
- The Cleveland Clinic Foundation
- Dr. Dennis Sprecher
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- American Heart Association, November 2000
- Arteriosclerosis, Thrombosis and Vascular Biology,
April 2002
- Global Atherosclerosis Symposium, June 2002
- Published in Atherosclerosis, December 2003
- Arteriosclerosis, Thrombosis and Vascular Biology,
April 2005
- Published in Atherosclerosis, August 2005
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Completed |
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Pediatric Pilot Study
- St. Joseph’s Healthcare
- Dr. Katherine Morrison
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- Endocrine Society, June 2003
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Completed |
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Framingham and Inflammatory Markers Study
- University of British Columbia
- Dr. John Mancini
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- Published in American Journal of Cardiology, June 2002
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Completed |
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Skin Cholesterol and Statins
- University of Vienna (independent study)
- Dr. Marcus Reiter
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- Published in Journal of Clinical Chemistry, January 2005
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Completed |
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Skin Cholesterol and Carotid IMT
- University of Wisconsin
- Dr. James Stein
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- American College of Cardiology, March 2005
- Published in American Heart Journal, December 2005
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Completed |
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PRACTICE (Prospective Assessment of Cardiovascular Risk and Treatment in Canadians of Varying Ethnicity)
- William Osler Health Centre
- Dr. Milan Gupta
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- Canadian Cardiovascular Congress, October 2004
- Canadian Cardiovascular Congress, October 2005
- Arteriosclerosis, Thrombosis and Vascular Biology Conference, April 2006
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Completed |
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PASA (Predictor of Subclinical Atherosclerosis)
- University of Wisconsin and multiple sites
- Dr. James Stein
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- Published in American Journal of Cardiology, April 2008
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Completed |
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ARISE (Aggressive Reduction of Inflammation Stops Events)
- AtheroGenics, Inc., conducted at multiple sites
- Dr. Rob Scott
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Data Analysis in Progress |
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MESA (Multi-Ethnic Study of Atherosclerosis)
- Johns Hopkins University
- Dr. Pamela Ouyang
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- American Heart Association, November 2003
- Published in Atherosclerosis, July 2005
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In progress |
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Framingham Risk Factor Comparison (All Comers’ Study)
- The Cleveland Clinic Foundation
- Dr. Dennis Sprecher
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Completed |
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Correlation Study
- Montreal Heart Institute and other sites
- Dr. Jean-Claude Tardif
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Data Analysis in Progress |
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Skin Cholesterol and New Coronary Artery Disease Risk Factors
- University of British Columbia
- Drs. John Mancini, Sammy Chan and Jiri Frolich
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In progress |
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PREPARE (PREVU* Predicts Atherosclerosis Risk and Events)
- Multi-site
- Drs. David Waters, Dennis Sprecher and John Mancini
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Data Analysis in Progress |
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ColorectAlert™
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Trial
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Publications/Presentations
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Status
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ColorectAlert™, FOBT, CEA and Colonoscopy Study
- St. Michael’s Hospital
- Dr. Norman Marcon
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- Digestive Diseases Week, May 2000
- American Association for Clinical Chemistry, July 2000
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Completed |
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Expanded ColorectAlert™ Studies
- St. Michael’s Hospital
- Dr. Norman Marcon
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- American Association for Cancer Research, July 2003
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Completed |
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U.S. National Cancer Institute EDRN Study
- Multiple sites
- Dr. Dean Brenner
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In progress |
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LungAlert™
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Trial
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Publications/Presentations
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Status
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LungAlert™ Pilot Trial
- St. Joseph’s Healthcare
- Drs. John Miller and Gerry Cox
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- American Thoracic Society, May 2001
- Published in Journal of the Clinical Ligand Assay Society, Spring 2002
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Completed |
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LungAlert™ Smokers’ Study
- St. Joseph’s Healthcare
- Drs. John Miller and Gerry Cox
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- American Association for Cancer Research, July 2003
- American Thoracic Society, May 2004
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Data Analysis in Progress |
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I-ELCAP (International Early Lung Cancer Action Program)
- Princess Margaret Hospital
- Dr. Heidi Roberts
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In progess |
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New LungAlert™ Test Format |
- American Association for Clinical Chemistry, July 2006
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Completed |
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Breast Cancer Test
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Trial
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Publications/Presentations
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Status
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Pilot Study
- M.D. Anderson Cancer Center
- Dr. Anees Chagpar
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- American Association for Cancer Research, July 2003
- Published in journal Cancer, July 2004
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Completed |
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Pivotal Study
- University of Louisville
- Dr. Anees Chagpar
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In progress |
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Related Publications
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PREVU*
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- Sprecher, D.L., Pearce, G.L. “Skin Cholesterol Adds to Framingham Risk Assessment.” Presented at 6th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology, April 30, 2005.
- Sprecher, D.L., Goodman, S.G., Kannampuzha, P., Pearce, G.L., Langer, A. “Skin tissue cholesterol (SkinTC) is related to angiographically-defined cardiovascular disease.” Atherosclerosis, 171 (2003): 255–258.
- Mancini, J., Chan, S., Frohlich, J., Kuramoto, L., Schulzer, M., and Abbott, D. “Association of Skin Cholesterol Content, Measured by a Noninvasive Method, with Markers of Inflammation and Framingham Risk Prediction.” The American Journal of Cardiology, 2001; Vol 89, No. 11:1313–1316.
- Zawydiwski, R., Sprecher, D. L., Evelegh, M.J., Horsewood, P., Carte, C. and Patterson, M. “A novel test for measurement of skin cholesterol.” J Clinical Chemistry, 2001; Vol 47, No. 7:1302–04.
- Bhattacharyya, A.K., Connor, W.E. and Lin, D.S. “The origin of plant sterols in the skin surface lipids in humans: from diet to plasma to skin.” The J Invest. Derm., 1983; 80:294–296.
- Deloly, J., Murat, L., De Graeve, J., Thiers, J.C. and Bouissou, H. “Cutaneous cholesterol assay using a micromethod and punchbiopsy in the detection of early atherosclerosis.” Path. Biol., 1980; 28:669–670.
- Lopukhin, Y.M. “The Skin and Atherosclerosis (a three-drop test).” Physicochemical Aspects of Medicine Reviews, 1992: Vol 3 1–121.
- Nishikawa, M., Nojima, S., Akiyama, T., Sanakawa, U and Inoue, K. “Interaction of digitonin and its analogs with membrane cholesterol.” J. Biochem., 1984; 96:1231–1239.
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Cancer
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- Diamandis, E.P., et.al. (Eds.) “Measurement of Hue and Chroma in Assessment of Biomarkers of Colon and Lung Cancer.” Chapter 48. Tumor Markers, Physiology, Pathobiology, Technology, Clinical Applications. AACC Press, Washington, 2002.
- Evelegh, M.J. “A Novel Method for the Quantification of the Galactose Oxidase-Schiff’s Reaction and Its Use in Cancer Detection.” Journal of Clinical Ligand Assay., 2002; 25:91–94.
- Shamsuddin, A.M., Tyner, G.T., and Yang, G.Y. “Common expression of the tumor marker D-Galactose-B-[1-3]-N-Acetyl-D-Galactosamine by different adenocarcinomas: Evidence of Field Effect Phenomenon.” J. Cancer Research, 1995; 55:149–152.
- Shamsuddin, A.M. “A Simple mucus test for cancer screening.” Anticancer Research, 1996; 16:2193–2200.
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